Prometheus – A captivating tale of Liver Regeneration.

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To a New Yorker this is a very familiar statue. To a tourist and a world traveller it is a precious memory.

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I first heard the name “Prometheus” when I visited Rockefeller Center in New York and saw the iconic sculpture.

My today’s story is about Prometheus and his link to Pathology of Liver Regeneration.

According to ancient Greek belief, Prometheus was one of the Titans, a group of gods even older than the Gods of Olympus led by Zeus. Some stories told how Prometheus created man, first making images in the likeness of gods and then giving these images life. After he had put them on earth he gave them a torch which he had lighted at the chariot of sun, and in this way men first got fire.

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 Image: Wikimedia commons  Prometheus Carrying Fire By Jan Cossiers
Image: Wikimedia commons: Prometheus Brings Fire to Mankind by Heinrich Füger

“If the first Prometheus brought fire from heaven in a fennel-stalk, the last will take it back — in a book.- John Cowper Powys.”

The younger god Zeus later took away this gift of fire when he quarrelled with the people on the earth, but Prometheus discovered where he had hidden it and brought it back again. In revenge Zeus chained Prometheus to a rock in the Caucasus Mountains and sent an eagle to eat his liver. The most interesting part of this story is that Prometheus was immortal and the liver grew back to its original size again in the night. Day after day the eagle came back and ate it again.

V0041859 Prometheus bound to a rock, his liver eaten by an eagle and Credit: Wellcome Library, London. Wellcome Images images@wellcome.ac.uk http://wellcomeimages.org Prometheus bound to a rock, his liver eaten by an eagle and his torch dropped from his hand. Engraving with etching. Published: - Copyrighted work available under Creative Commons Attribution only licence CC BY 4.0 http://creativecommons.org/licenses/by/4.0/
( Prometheus bound to a rock, his liver eaten by an eagle and
Credit: Wellcome Library, London. Wellcome Images
images@wellcome.ac.uk
http://wellcomeimages.org)

At one time Zeus offered to release him if he would reveal a secret which threatened the rule of the Gods, but Prometheus refused to be freed in this way. He bore his torture because he knew that in 13th generation a son of Zeus would save him. That is exactly what happened, for the hero Hercules, who was one of Zeus’s sons, killed the eagle and set Prometheus free.

Stories of punishment of Prometheus are frequently used by lecturers on liver regeneration.

According to Dr Chen et al  liver was considered immortal not only because of it’s power of regeneration but because ancient Greeks believed that the liver was the seat of soul and intelligence.  It is clear that ancient Greeks knew about liver’s potential for repair. The fact that the organ grew at night as the eagle ate all day indicates the rate of hepatic regeneration. According to the myth the eagle came every other day, allowing full day to regenerate. The author concluded that the close match between the amount of  liver tissue removed by the eagle, the amount and appropriate rate of recovery suggested that the ancient Greeks had some idea about hepatic regeneration.

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 10  facts about Hepatic Regeneration:

  • The normal liver consists of a stable population of hepatocytes with a slow turnover rate.
  • It has a remarkable capacity for regeneration. It can restore approximately three-quarters of its own mass within within six months.
  • After surgical resection and during recovery from submassive liver necrosis, upto 70% of the human liver regenerate.
  • In experimental animals  (rat liver) the hepatocytes have an annual turnover of one mitosis per year. After partial hepatectomy there is a burst of mitotic activity so that the liver weight doubles within 48 hours and return to normal weight after 3 to 6 days.
  • In human liver, regeneration also occurs rapidly. This is noted in cirrhotic liver.
  • After major hepatic resection for tumour, regeneration of normal hepatic volume occurs by 3 to 6 months, and liver function appears normal  within 2 to 3 weeks after surgery.
  • Many factors influence regeneration but the precise triggers which stimulate increased mitotic activity are still unknown.
  • Hepatic growth factor regulators can be broadly divided into groups : nutrients and hormones, polypeptide growth factors not necessarily specific to the liver and serum or liver-derived growth factors with greater specificity for the liver than other tissue.
  • The responsiveness of hepatocytes is strongly influenced by their metabolic state.
  • Epidermal growth factor may be one of the hepatotrophic factors with an important role in maintaining hepatocellular function and aiding cellular repair and regeneration.

All those interested in Liver pathology and regenerative medicine will continue to be enthralled by the interesting story of Prometheus, the Greek Titan, who brought fire to mankind. A mythical character whose liver grew back every night after it was torn and eaten everyday by an eagle.

Reference:

Prometheus bound: evolution in the management of hepatic trauma–from myth to reality.

Whither prometheus’ liver? Greek myth and the science of regeneration.

Promethean medicine: spirituality, stem cells, and cloning.

The myth of Prometheus mirrored in intensive medicine.

Hepatic Regeneration-Revisiting the Myth of Prometheus.

Liver regeneration. The Prometheus myth in the light of molecular biology.

Liver regeneration 7. Prometheus’ myth revisited: transgenic mice as a powerful tool to study liver regeneration.

The myth of Prometheus and the liver.

Myth of Prometheus in experimental reality; biochemical researches on the regeneration of the liver.

A20–an omnipotent protein in the liver: prometheus myth resolved?

 Image Courtesy: pixabay.com

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