Giant cell angiofibroma : A soft tissue tumour with Floret-like giant cells [Pathology Infographic]

A giant cell rich form of hemangiopericytomas-solitary fibrous tumors was described by Dei Tos as  Giant cell angiofibroma (GCA).

Although originally identified in the orbital region, this tumor may occur in diverse locations.

GCAs are well-circumscribed variably encapsulated, small (median, 3 cm) lesions.

The morphological hallmark is a richly vascularized spindle cell proliferation containing pseudovascular spaces and floret -like multinucleate giant cells.

Mitotic activity range from 1 to 3 mitoses/10 high-power fields.

Treatment of GCA consists of simple tumorectomy.


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