What is Rosai Dorfman Disease ? [Pathology Infographic]

Rosai- Dorfman Disease is a rare benign histiocytic disorder in which patients present with painless cervical lymphadenopathy, fever and leukocytosis. The classical findings include emperipolesis and histiocytes staining positive for S100 protein and CD68 and negative for CD1a.



Visit: Histopathology-india.net.

Think before you drink – Beware of Holiday Heart Syndrome [Pathology Infographic]


Everyone was in a festive spirit. He was a healthy 50 year old man  dancing,  drinking and enjoying with his friends. One glass of wine was not enough. He consumed many glasses of alcohol  in a short span of time. Suddenly he started sweating, complained of cardiac pain, severe palpitations and respiratory distress. Finally he lost  consciousness and collapsed on the floor.

What happened to him ? 


Locally Aggressive Adnexal Tumour – Microcystic Adnexal Carcinoma [Pathology Infographic]

A slow growing locally aggressive adnexal tumour  presented as a plaque on the cheek of an elderly male.

 Just on Hematoxylin and eosin stain search for ductal structures, perineural invasion and deep invasion into the subcutaneous fat.

Immunohistochemistry will finally establish the diagnosis. Pathology of Microcystic Adnexal Carcinoma



[Pathology Infographic]- A Slow growing malignant tumour- Aggressive Digital Papillary Adenocarcinoma


Aggressive digital papillary adenocarcinoma is a slow growing, painless malignant sweat gland tumour. It is a rare life-threatening malignant tumour  and the diagnosis is easily missed or delayed. Both clinician and pathologist should keep this rare condition in mind when dealing with  tumours of the digits.

It is usually located on the fingers.  The tumour enlarges over several years.  Patients are usually elderly male (50 -70 year old). The clinical presentation is often confusing and can be easily misdiagnosed  for a benign lesion  such as a ganglion cyst, pyogenic granuloma, or soft-tissue infection.

Microscopic diagnosis is also challenging and it can be wrongly diagnosed as a metastatic papillary adenocarcinoma originating in the colon, thyroid, or breast. Clinicopathological correlation is  essential to rule out a possible risk of metastatic carcinoma of the skin.

These are aggressive lesions which can often recur, metastasize to distant sites, and invade local tissues including bone.

Aggressive treatment like amputation of the finger is recommended for this aggressive tumour.